Our TUDCA vs. other brands
tested
TUDCA purityEurofins lab test
Daily doseper serving
Human research on TUDCA has used 500mg a day. Brands with lower purity often tell you to take more.
- One ingredient, no fillers or flow agents
- Research-backed 500mg daily dose
- Purity verified by Eurofins
TUDCA 500mg
- Healthier Bile Flow
- Helps with fat digestion
- Gallbladder comfort
- Protects liver cells
- Eases fatty-meal discomfort
- Mitochondrial function
Our TUDCA vs. other brandstested
TUDCA purityEurofins lab test
Daily doseper serving
Human research on TUDCA has used 500mg a day. Brands with lower purity often tell you to take more.
- One ingredient, no fillers or flow agents
- Research-backed 500mg daily dose
- Purity verified by Eurofins
Details
Supplemental TUDCA helps support healthy bile flow, fat digestion, and normal liver function. Beyond digestion, TUDCA has also been studied for its role in cellular health, including its effects on cellular stress and mitochondrial function.
By supporting the systems involved in bile function and fat metabolism, TUDCA provides targeted support for healthy digestion, nutrient absorption, liver function, and overall cellular health.
Benefits
- Everyday liver support
- ALT, AST or GGT drifting up on a routine panel is the most common trigger for a first order. TUDCA supports normal liver function while you and your GP watch the numbers.
- Works without a gallbladder
- No reservoir means bile trickles rather than surges, and fat-heavy meals are the tell. TUDCA is a water-soluble bile acid, so it still works with no gallbladder to concentrate it.
- Comfort after fatty meals
- Fat that is not emulsified upstream ferments downstream. TUDCA supports the bile flow that breaks fat into droplets your enzymes can reach.
- Keeps up with a high-fat diet
- Keto and carnivore put a standing demand on bile production that most people never think about. TUDCA supports the bile side of that load.
- Support when the liver works harder
- TRT and oral compounds raise the liver's workload, and that raises the case for bile-side support. TUDCA helps protect liver cells working under load.
- Digestion that keeps moving
- Bile acids are a natural motility signal in the colon, and bile is antimicrobial in the small intestine. Low flow slows things down; TUDCA supports normal flow.
What to Expect
- 0–2 Weeks TUDCA begins working on stagnant bile viscosity immediately upon ingestion. While complete flow restoration is a gradual, cumulative process, some users report experiencing early, partial relief from post-meal heaviness within the first 7 to 14 days.
- 2–4 Weeks Meals tend to sit differently. Fat-heavy food stops feeling like a decision, and many people report less bloating in the evening.
- 4 Weeks and Beyond Digestion steadies, with more consistent bowel habits and steadier energy after meals. If you started because of a blood panel, around week eight is a sensible point to retest.
Suggested Use
Take 1–2 capsules with food, or follow the recommendations of your healthcare professional.
If you are pregnant or nursing, speak with a qualified healthcare professional before use.
Ingredients
| Serving Size: 2 CapsulesServings per Container: 30 | ||
|---|---|---|
| Amount per Serving | % Daily Value | |
| Tauroursodeoxycholic Acid | 500mg | † |
| † Daily value not established | ||
Other ingredients: Gelatin (capsule), rice flour
FAQs
What is TUDCA and what does it actually do?
TUDCA (Tauroursodeoxycholic Acid) is a naturally occurring, hydrophilic bile acid that thins out thick, stagnant bile upstream before it exits your stomach. By acting as your body’s natural “dish soap,” it emulsifies dietary fats so your enzymes can digest them—preventing raw fats from traveling downstream to ferment and inflate your midsection.
I’ve had my gallbladder removed / I have gallstones. Is this for me?
Without a gallbladder: Yes. Your liver now drips raw bile continuously instead of on-demand, leaving mealtimes chemically unprepared to process fats. TUDCA optimizes bile composition to ensure proper fat breakdown.
If you worry about gallstones: Thick, stagnant bile stasis is the primary precursor to stone crystallization. Actively thinning this sluggish fluid directly prevents the stasis that allows solid deposits to form.
I’ve already tried milk thistle, ox bile, enzymes, and probiotics. Why is this different?
- Probiotics & Enzymes: Probiotics add bacteria to an already fermented downstream swamp, while supplemental enzymes fail because lipase cannot physically penetrate fat globules without thin bile prepping them upstream.
- Milk Thistle: This is a gentle liver antioxidant that has zero mechanical thinning effect on thick biliary sludge.
- Ox Bile: This is a crude, animal-sourced extract that is highly acidic and frequently causes burning, farmyard-tasting acid reflux. TUDCA is highly refined, gentle on the duodenum, and coaxes your system to thin its own bile.
Is it safe, and how long before I notice a difference?
Because TUDCA is an organic acid your body already recognizes, it is exceptionally gentle. Our formulation contains zero synthetic flow agents, silicon dioxide, or magnesium stearate to prevent duodenal irritation.
Restoring physical fluid mechanics is gradual. While initial digestive comfort often begins within 7 to 14 days, and many users report near instant relief, complete biliary flow normalization and systemic restructuring typically require 30 to 90 days of consistent daily mealtime use.
- Free UK delivery every 4 weeks
- Cancel, pause or skip anytime
- 30-day money-back guarantee
Plan details
Your subscription renews automatically every 30 days at the price shown, and we ship each order as it renews. There is no minimum term: you can skip, pause, change the quantity or cancel at any time from your account page, or by emailing help@drprimal.com.
- Free UK delivery on every subscription Free UK delivery
- One ingredient, 500mg per serving 500mg per serving
- 100% Purity TUDCA
- 30-day money-back guarantee 30-day money back
4 Ways TUDCA supports your body.
Read more
Healthy Bile Flow
Helps keep bile moving efficiently, supporting the liver’s natural process of carrying fats, cholesterol and waste into the digestive tract.
Read more
Liver Cell Protection
Helps protect liver cells from cellular stress, supporting healthy liver function when those cells are working under load.
Read more
Fat Digestion
Helps your body break down and absorb dietary fats, supporting more comfortable digestion after heavier, higher-fat meals.
Read more
Mitochondrial function
Supports healthy mitochondrial function, helping your cells efficiently produce the energy they need to function.
What customers report back
Self-reported, from a survey of Dr.Primal customers at twelve weeks.
- 82% said fatty meals were easier after 12 weeks
- 4.8/5 average rating from 1051 verified customers
- 3 weeks median time to a first noticed change
- 9 in 10 reordered after their first bottle
4.8 out of 5, from 1051 verified customers
Verified purchases. Edited only for length.
Gallbladder out in 2019 and fatty meals had been a gamble since. Three weeks in, that gamble is mostly gone.
Taking it because my GGT crept up. I cannot tell you what my bloods look like yet, but digestion is calmer and I am sticking with it.
Carnivore for two years and fat was still sitting heavy. Taking it with the first meal sorted that out.
On TRT and wanted something for the liver that was not a twelve-herb blend. One ingredient, one dose, nothing else in the capsule. Easy decision.
Bloating after any oily meal, plus a sluggish gut. Two weeks before I noticed anything, then a clear difference.
Enzymes flagged at a medical, so I went looking for bile acids rather than another blend. Straightforward label, no theatre.
Gallbladder out in 2014. The first month I did not notice much. The second month I stopped planning my days around the bathroom.
I train fasted and eat one big meal at night. The food coma after it used to write off my evening. Milder now, most nights.
Bought it for my husband after his scan came back clear but fried food still would not agree with him. He eats with the rest of us again.
Two capsules with dinner, that is the whole routine. No taste, no repeating on me, and the Sunday roast sits like it used to.
Sceptical, because I have a drawer full of things that did nothing. This one is on its third reorder, which says more than I can.
My ALT was the reason I started. I retest in the spring, but meals sit lighter and that alone keeps me taking it.
Six reasons people start
Most people arrive at TUDCA sideways: through a blood test, a surgery, or a diet that leans hard on fat. Pick the one that sounds like you.
Swipe through and pick the one that sounds like you.
After gallbladder removal
No reservoir means bile trickles rather than surges. Fat-heavy meals are the tell.
Keto and carnivore
A high-fat diet puts a standing demand on bile production that most people never think about.
On TRT or oral compounds
Anything that raises the liver's workload raises the case for bile-side support.
Raised liver enzymes
ALT, AST or GGT drifting up on a routine panel is the most common trigger for a first order.
Bile-driven constipation
Bile acids are a natural motility signal in the colon. Low flow can slow everything down.
SIBO and bloating
Bile is antimicrobial in the small intestine. When flow drops, overgrowth has an easier time.
Swipe for all six
Your timeline, week by week
Nothing here happens overnight. Here is a realistic timeline, based on what TUDCA has been studied for and what our customers report.
-
Days 1–7
Nothing much, and that is normal
- A few people notice looser stools as bile flow shifts
- If your stomach objects, move the capsules to a meal
-
Weeks 2–3
Meals sit differently
- Fat-heavy food stops feeling like a decision
- Less bloating in the evening
-
Weeks 4–8
Digestion steadies
- More consistent bowel habits
- Many report steadier energy after meals
-
Weeks 8–12
Worth retesting
- If you started because of a blood panel, retest now
- Keep going, the benefit is in the consistency
Can I take TUDCA if my gallbladder has been removed?
Yes, it is one of the most common reasons people take it. Without a gallbladder, bile drips into the gut continuously rather than being released in a concentrated burst. TUDCA is a water-soluble bile acid, so it supports that flow. Take it with your largest meal of the day.
How long before I notice anything?
Digestive changes are usually the first thing people report, typically within two to three weeks. Anything you would measure on a blood panel takes longer: retest after 8 to 12 weeks of consistent use.
How does the subscription work, and how do I cancel?
Your first order ships the next working day, then again every one, three or five months depending on the size you chose. Cancel, pause or change the date from your account or by replying to any of our emails. There is no phone menu and no minimum term.
Can I take it alongside my medication?
TUDCA is a food supplement and is not commonly known to interact with medication, but we are not able to give medical advice. If you take prescription medicine or have a diagnosed liver condition, speak to your GP or pharmacist before starting.
Why 500mg, and why two capsules?
Most human research on bile flow and liver markers sits in the 500–1,500mg per day range. A 500mg serving is two capsules, so you can start at the low end and build up on your own terms rather than opening capsules to split a scoop.
What is actually in the capsules?
500mg of tauroursodeoxycholic acid per serving, and hypromellose vegetable capsule shells. No magnesium stearate, no colourings.
Dr.Primal TUDCA 500mg is a food supplement and is not intended to diagnose, treat, cure or prevent any disease. Do not exceed the recommended dose. Not suitable if you are pregnant or breastfeeding. If you take prescription medication or have a diagnosed liver or gallbladder condition, speak to your GP or pharmacist first.
