tested
TUDCA purityEurofins lab test
Daily doseper serving
Human research on TUDCA has used 500mg a day. Brands with lower purity often tell you to take more.
tested
TUDCA purityEurofins lab test
Daily doseper serving
Human research on TUDCA has used 500mg a day. Brands with lower purity often tell you to take more.
Your gallbladder never made bile. Your liver does. The gallbladder stored it, concentrated it, and released a strong dose the moment food arrived. After removal, bile keeps coming, but it drips into the gut all day instead of arriving with your meal.
TUDCA is a naturally occurring bile acid your body already makes. Taken with meals, it supports healthy bile flow and the digestion of fat, right when you eat.
After gallbladder removal, bile flows directly from the liver into the small intestine. TUDCA is a hydrophilic bile acid that helps support the body's bile acid balance and normal digestive function.
Without a gallbladder to store and release concentrated bile, fatty meals can be harder to digest. TUDCA supports healthy bile composition and flow, helping the body's natural fat-digestion process.
Unlike more hydrophobic bile acids, TUDCA is water-loving and known for its comparatively low cellular toxicity. It supports the bile acid pool without relying on animal-derived ox bile.
Bile plays an essential role in absorbing vitamins A, D, E, and K. TUDCA supports the bile acid environment involved in the body's natural absorption of these essential nutrients.
Even without a gallbladder, the liver continues producing bile every day. TUDCA supports healthy bile acid composition and normal liver function, helping maintain the body's natural bile circulation.
Two capsules (500mg) with your largest meal, ideally the one with the most fat.
Not suitable during pregnancy or breastfeeding, or under 18. If you take prescription medication, including a bile acid binder, speak to your doctor or pharmacist first.
| Serving Size: 2 CapsulesServings per Container: 30 | ||
|---|---|---|
| Amount per Serving | % Daily Value | |
| Tauroursodeoxycholic Acid | 500mg | † |
| † Daily value not established | ||
Other ingredients: Gelatin (capsule), rice flour
TUDCA (Tauroursodeoxycholic Acid) is a naturally occurring, hydrophilic bile acid that thins out thick, stagnant bile upstream before it exits your stomach. By acting as your body’s natural “dish soap,” it emulsifies dietary fats so your enzymes can digest them—preventing raw fats from traveling downstream to ferment and inflate your midsection.
Without a gallbladder: Yes. Your liver now drips raw bile continuously instead of on-demand, leaving mealtimes chemically unprepared to process fats. TUDCA optimizes bile composition to ensure proper fat breakdown.
If you worry about gallstones: Thick, stagnant bile stasis is the primary precursor to stone crystallization. Actively thinning this sluggish fluid directly prevents the stasis that allows solid deposits to form.
Because TUDCA is an organic acid your body already recognizes, it is exceptionally gentle. Our formulation contains zero synthetic flow agents, silicon dioxide, or magnesium stearate to prevent duodenal irritation.
Some people notice a difference in digestive comfort within the first two weeks; for others it takes longer. Most take it daily with meals for 30 to 90 days before judging it. Everyone’s experience is different.
TUDCA is a naturally occurring bile acid that supports several important processes in the body. Long revered in traditional medicine, it continues to be studied for a range of potential health benefits.
Read more
Helps keep bile moving efficiently, supporting the liver’s natural process of carrying fats, cholesterol and waste into the digestive tract.
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Helps protect liver cells from cellular stress, supporting healthy liver function when those cells are working under load.
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Helps your body break down and absorb dietary fats, supporting more comfortable digestion after heavier, higher-fat meals.
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Supports healthy mitochondrial function, helping your cells efficiently produce the energy they need to function.
Engineered for targeted delivery and better tolerance
Our enteric Gut Deliver™ Capsules use a specialized pH-sensitive coating designed to remain intact in the highly acidic environment of the stomach and begin dissolving as they reach the higher-pH environment of the intestinal tract.
By minimizing the amount of TUDCA released in the stomach, Gut Deliver™ is designed to limit unnecessary stomach exposure to bile acids while delivering TUDCA further along the digestive tract — closer to its primary site of absorption.
Includes reviews from our wholesale and retail customers.
If you suffer from frequent diarrhea due to not having a gallbladder this stuff works wonders. I also experienced frequent painful stomach cramps after eating in the morning that would lead to explosive diarrhea. It’s gone.
Samantha R.
I was able to eat foods that had previously caused me discomfort (especially anything with fat; I have no gallbladder now), and I no longer experienced bloating or gas after meals.
Maya P.
I was in too much pain because of the gallbladder removal, but with this, at least I can eat meat without bothering me.
Elena R.
I was starting to doubt TUDCA was for me after trying it without results, but a friend recommended Dr. Primal, and I am glad I tried!
Bernard S.
Thank you, this didn’t cause stomach irritation or heartburn, unlike the cheaper Amazon alternatives.
Owen H.
I used to take 3-4 different medications for my bloating. Turns out two of these pills per day was enough. Feeling much better thanks to Dr. Primal.
Sylvia F.
Taking Dr. Primal TUDCA before eating completely stopped the post-meal bloat. My stomach stays flat all evening.
Peter D.
I used to feel like I had a brick in my stomach after every meal. The fat breakdown is very noticeable. Zero heaviness for the last month now.
Samantha R.
Tried enzymes, ox-bile, milk thistle, etc. Some didn’t help, some gave new side effects. I guess TUDCA was the missing piece - my digestion was back on track in two weeks.
Hannah M.
Taking TUDCA while on TRT for last 4 years on and off. Dr. Primal is hands down the most potent and high quality feeling product on the market.
Matt J.
Most liver supplements are packed with silicon dioxide and cheap flow agents. Dr. Primal gives you 100% active TUDCA that supports liver filtration with zero stomach irritation.
Evelyn D.
I eat Keto every second quarter to fix my metabolism. Used to come with cramps, but Dr. Primal TUDCA has done wonders with this, and now my Keto periods are much more pleasant.
Sergey C.
Food used to pass right through me whenever I increased my daily fat macros. Your TUDCA fixed the upstream bottleneck, letting me digest heavy fats without emergency room visits
Anonymous
Switching to Keto left me feeling heavy and bloated after fatty dinners. This is the first reddit find that actually paid off - bile thinning does work wonders!
David L.
Fixing my biliary mechanics did more for my everyday energy than any supplement stack I’ve tried.
Dana W.
I tried everything for chronic slumps until my nutritionist pointed to poor fat digestion. TUDCA was the missing link - I feel light, alert, and energized all day.
Eric K.
I tell my clients that chronic tiredness often starts in the liver and gallbladder. Dr. Primal TUDCA restores clean fat digestion, helping my patients regain clear, alert energy without relying on extra stimulants.
Philip M.
Compare both TUDCA and Dr. Primal against other alternatives. Click any of the icons in the chart for more information.
| Feature | 
 TUDCA | 
Ox bile | 
Milk thistle | 
Digestive enzymes | 
Probiotics |
|---|---|---|---|---|---|
| Targets the top of digestion | |||||
| Fat emulsifying properties | |||||
| Gentle, water-soluble formula | |||||
| Naturally occurring in the body | |||||
| Supports bile flow | |||||
| Studied for cellular support |
* Based on typical formulations and commonly documented properties. Specific products may differ.
| Feature |
TUDCA | 
Other brands |
|---|---|---|
| Independently lab tested | ||
| Clean-label excipients | ||
| 99%+ purity | ||
| Research-backed 500mg dose | ||
| Single active ingredient | ||
| 30-day money-back guarantee |
* Based on typical formulations and commonly documented properties. Specific products may differ.
4.8
4.8 out of 5 average rating from 1,051 customer reviews
82%
82% of customers reported improved upper abdominal comfort after taking TUDCA by Dr. Primal Based on a Dr. Primal 2026 observational study of consumer perception, 300 participants, after 12 weeks of use.
3/4
3 in 4 TUDCA by Dr. Primal buyers choose a monthly subscription.
Less than 0.9% of Dr. Primal customers used their 30-day money-back guarantee
Always listen to your body. Individual experiences may vary. Timelines are illustrative and results are not guaranteed. Consult your healthcare provider before starting any new supplement.
Start using TUDCA
by Dr. Primal.
TUDCA begins working on stagnant bile viscosity. Restoration is a gradual process. Some users report early, partial relief from digestive symptoms.
Fluid bile flow improves, helping emulsify dietary fats higher up in the gut. Many notice a reduction in heavy bloating and lower gas.
Continued daily use supports healthy bile flow and liver cell function. Many describe renewed trust in their digestive system and freedom from mealtime anxiety.
Continued use promotes sustained digestive comfort, renewed daily energy, and improving of general gut health.
TUDCA (tauroursodeoxycholic acid) is a naturally occurring, water-loving bile acid that supports liver health and healthy bile composition. After gallbladder removal, bile flows directly from the liver into the intestine rather than being stored and concentrated. TUDCA supports the body's natural bile acid balance, which plays an essential role in fat digestion and nutrient absorption.
TUDCA is a hydrophilic (water-loving) bile acid, unlike some of the more hydrophobic bile acids found in ox bile. It is known for its relatively gentle cellular profile, although digestive tolerance varies. Some people may experience mild stomach discomfort or loose stools, particularly when first starting.
Take 500 mg daily (2 capsules), preferably with a meal. Consistent daily use is recommended over occasional supplementation. If you've recently had gallbladder surgery, consult your surgeon before starting and wait until you've recovered sufficiently to resume your normal diet.
Dr. Primal TUDCA is independently third-party tested for purity, potency, and heavy metals, including testing by Eurofins. Our clean-label formula contains organic rice flour, with no silicon dioxide, magnesium stearate, or unnecessary additives.
TUDCA is a naturally occurring bile acid that has been studied for daily use. There is no established requirement to cycle it.
Generally, TUDCA can be combined with common supplements, including multivitamins, probiotics, and digestive enzymes. However, certain medications, particularly bile acid binders such as cholestyramine, may interfere with its absorption. Consult your doctor or pharmacist before combining TUDCA with prescription medications.
Go to drprimal.com/account and sign in with the email address you ordered with. We email you a 6-digit code, so there is no password to remember. Open Subscriptions, choose your plan, and pause or cancel it there. There is no minimum term. If you would rather we did it, email help@drprimal.com or reply to any of our emails.
