Bile, liver and digestion, explained honestly
What the research shows, where it stops, and how to tell whether it applies to you.
What TUDCA actually is, and what the evidence says
A bile acid the body already makes, sold as a supplement. Here is what it does, what the research says, and where the evidence...
Why standard liver support fails when bile flow is the bottleneck
When liver markers run high and the usual supplements do nothing, the problem may not be cellular damage — it may be a fluid...
The upstream science of bile viscosity
If your scans are clear and the bloating is not, the problem may be upstream of the gut — in the viscosity of the...
Why the bloating persists when every scan is clear
Your scans came back clear. Your bloating did not. The explanation may be upstream of where everyone has been looking. Across the UK, thousands...
The upstream experiment: how a gym supplement addressed the bloat my doctors labelled IBS
Three years of clear scans, an IBS label, and a cupboard full of half-finished bottles — until a lifting buddy asked the one question...
Your macros are perfect. Your bile is sluggish.
You track every macro, every set, every recovery variable. The one system you have never programmed is the fluid that actually digests the food....
After gallbladder removal: the timing problem nobody explains
Most people recover from gallbladder removal without trouble. For the minority whose digestion changes afterwards, the explanation arrives years late — if it arrives...
TolerabilityHow well is TUDCA actually tolerated?
Two questions, one post. Why some people get diarrhoea in the first week, and what happens to people who take it for eighteen months.
Pre-clinical researchThe gut-liver axis, and what a mouse study can and cannot tell you
An animal study on bile acids and the microbiome produced striking numbers. Those numbers are from mice, and that qualification is the point.
Cell biologyWhat a chemical chaperone actually is
TUDCA's most-cited mechanism has nothing to do with digestion. Here is what the primary study found, including the part that does not flatter it.
Digestive enzymesWhy lipase supplements fail on their own
Lipase is water-soluble and fat is not. Without emulsification first, the enzyme has almost nothing to grip.
Target organMilk thistle and TUDCA are not competing
They act on different tissue. If your problem is mechanical, the most heavily marketed liver supplement in the world is aimed at the wrong...
